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Natural compounds identified as potential inhibitors of SARS CoV 2 spike protein

Several drugs have been identified that show promise in treating COVID-19, including antiviral drugs, immunomodulatory drugs, and other therapies. These drugs have been investigated for their potential to reduce viral load, modulate the immune response, and prevent severe illness. Several drugs have been specifically identified as having antiviral properties against SARS-CoV-2, including remdesivir, lopinavir/ritonavir, and chloroquine.

The team also used a combination of biochemical and biophysical techniques to validate the efficacy of these compounds.

  • It is a type of fusion protein, consisting of two subunits: S1 and S
  • The S1 subunit is responsible for binding to host cell receptors, while the S2 subunit facilitates membrane fusion and viral entry.
  • The spike protein’s structure is highly dynamic, allowing it to undergo conformational changes in response to host cell receptors.Molecular Docking Analysis
  • The research team employed molecular docking analysis to screen a diverse library of natural compounds that could act against the spike protein.

    These compounds have been linked to the antibacterial, antifungal, antiviral, and anticancer properties of the plant. Summary of Cephaline: Cephaline is a natural compound found in the plant’s roots. It has shown promise in treating respiratory infections, such as bronchitis and pneumonia, due to its antibacterial properties. Studies have indicated that cephaline can inhibit the growth of bacteria, including those responsible for tuberculosis, making it a potential treatment option for these diseases.

    The Importance of Computational Models in Drug Discovery

    Computational models play a vital role in the field of drug discovery, enabling researchers to simulate and predict the behavior of molecules in various environments.

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